SAFE Act may refer to:

• Secure and Fair Enforcement Banking Act (SAFE Banking Act of 2019), a bill to improve access to banking and financial services for cannabis businesses
• Secure and Fair Enforcement for Mortgage Licensing Act of 2008
• Securing Adolescents From Exploitation-Online Act of 2007.
• Security and Freedom Ensured Act of 2003.
• American Safety Against Foreign Enemies Act of 2015, the legislation requiring background investigations for refugees
• Safe Aviation Flight Enhancement Act, proposed in the US House of Representatives for deployable flight recorders
• Security and Freedom Through Encryption Act of 1999

• Save Adolescents From Experimentation (SAFE) Act of 2021, an Arkansas law banning doctors from providing gender-affirming healthcare to transgender youth
• New York Secure Ammunition and Firearms Enforcement Act (NY SAFE Act) of 2013, the New York gun control legislation
• Secure and Fair Elections Act, Kansas's Voter identification law, enacted in 2011